Left ventricular diastolic filling and its association with age

Thirty normal subjects, aged 22 to 80 years, were studied by radionuclide ventriculography to determine the age dependence of cardiac ventricular diastolic function and to evaluate the association of other factors with ventricular diastolic performance. A strong negative correlation was found betwee...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 58; no. 6; pp. 531 - 535
Main Authors Miller, Tom R., Grossman, Stanley J., Schectman, Kenneth B., Biello, Daniel R., Ludbrook, Philip A., Ehsani, Ali A.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.09.1986
Elsevier
Subjects
Adult
Aged
Aging
Biological and medical sciences
Cardiac Volume
Cardiovascular system
Diastole
Female
Heart - diagnostic imaging
Humans
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Contraction
Radionuclide Imaging
Technetium
Human
Heart
Left ventriculography
Young adult
Cardiovascular disease
Diastolic volume
Hemodynamics
Radioisotope
Elderly
Age
Left ventricle
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Summary:Thirty normal subjects, aged 22 to 80 years, were studied by radionuclide ventriculography to determine the age dependence of cardiac ventricular diastolic function and to evaluate the association of other factors with ventricular diastolic performance. A strong negative correlation was found between peak diastolic filling rate and age (r = −0.82, p < 0.0001). Partial correlation analysis was used to factor out the strong age dependence and yielded additional significant correlations of peak filling rate with heart rate (r = 0.48, p < 0.01) and time to peak filling rate (r = −0.48, p < 0.01). Time to peak filling rate is also correlated with heart rate but not definitely with age. Analysis by multiple linear regression yields an equation predicting peak filling rate from age and heart rate. Thus, the rate of rapid diastolic filling declines markedly with age in normal subjects. The association of peak filling rate with age and with other factors indicates the need for careful consideration of these factors in the interpretation of scintigraphic findings in patients with heart disease.
Bibliography:ObjectType-Article-1
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ISSN:0002-9149
1879-1913
DOI:10.1016/0002-9149(86)90028-7