T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis

To investigate the function of activated T lymphocytes in autoimmune chronic active hepatitis, 7 of 15 T-cell clones from the peripheral blood of 8 patients were studied. These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 o...

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Published inThe Lancet (British edition) Vol. 336; no. 8730; p. 1527
Main Authors Wen, L, Peakman, M, Lobo-Yeo, A, McFarlane, B M, Mowat, A P, Mieli-Vergani, G, Vergani, D
Format Journal Article
LanguageEnglish
Published England 22.12.1990
Subjects
Adolescent
Autoantibodies - immunology
Autoantibodies - physiology
Autoimmune Diseases - immunology
Cell Division
Child
Child, Preschool
Clone Cells - immunology
Female
Hepatitis, Chronic - blood
Hepatitis, Chronic - immunology
Humans
Male
T-Lymphocytes - physiology
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Summary:To investigate the function of activated T lymphocytes in autoimmune chronic active hepatitis, 7 of 15 T-cell clones from the peripheral blood of 8 patients were studied. These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 of these clones reacted with liver-specific lipoprotein complex, and 1 clone (and 3 subclones) responded to the asialoglycoprotein receptor (ASGPR), both known targets of immune attack in autoimmune chronic active hepatitis. 2 of these clones stimulated autologous B lymphocytes to produce liver-membrane-specific autoantibodies and antibody to the ASGPR. These results suggest that liver-membrane-specific activated T lymphocytes in peripheral blood may be important in the autoimmune attack of chronic active hepatitis.
ISSN:0140-6736
DOI:10.1016/0140-6736(90)93306-A