Anti-steroidogenic activity of the petroleum ether extract and fraction 5 (fatty acids) of carrot ( Daucus carota L.) seeds in mouse ovary

• Published in: Journal of ethnopharmacology Vol. 57; no. 3; pp. 209 - 212
• Main Authors: Majumder, P.K, Dasgupta, S, Mukhopadhaya, R.K, Mazumdar, U.K, Gupta, M
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.08.1997; Elsevier
• Subjects: Alkanes - pharmacology; Animals; Antifertility; antifertility agents; Antisteroidogenic; Ascorbic Acid - metabolism; Biological and medical sciences; Carrot; Chemical Fractionation; Cholesterol - metabolism; Daucus carota - metabolism; Estrus - drug effects; Fatty Acids - isolation & purification; Fatty Acids - pharmacology; Female; female fertility; General pharmacology; Glucosephosphate Dehydrogenase - antagonists & inhibitors; Isomerases - antagonists & inhibitors; Medical sciences; Medicinal plant; medicinal plants; Mice; Organ Size - drug effects; Ovary - drug effects; Ovary - enzymology; Ovary - metabolism; Petroleum; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Seeds; Asia; India; Carrot; Antisteroidogenic; Antifertility; Medicinal plant; Seeds; Estrus; Daucus carota; Pharmacognosy; Rodentia; Extract; Biological activity; Vertebrata; Mammalia; Folk medicine; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Female; Spermatophyta; Contraceptive; Steroidogenesis; Umbelliferae; Mechanism of action
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(97)00056-1

The petroleum ether extract and fraction 5 (fatty acids) of carrot seeds arrested the normal estrus cycle of adult mouse and reduced the weight of ovaries significantly. The cholesterol and ascorbic acid content in ovaries were significantly elevated due to the treatment with extract and fraction 5 (fatty acids) of carrot seeds. The significant inhibition of Δ5,3- β-hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase, the two key enzymes involved in ovarian steroidogenesis, were also observed in mouse ovaries after 15 days of treatment. Results of this study revealed that the fraction 5 (fatty acids) present in carrot seeds acts as an antisteroidogenic agent.