Pregnane glycosides from the leaves of Dregea volubilis and their α-glucosidase and α-amylase inhibitory activities

Three new pregnane glycosides, drevoluosides O-Q (1-3) along with five known volubiloside C (4), dreageoside A11 (5), 17β-marsdenin (6), stavaroside H (7), and hoyacarnoside G (8) were isolated from the methanol extract of the Dregea volubilis leaves. Their structures were elucidated by chemical and...

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Published inNatural product research Vol. 35; no. 21; pp. 3931 - 3938
Main Authors Thuy, Nguyen Thi Kim, Phuong, Phan Tuan, Hien, Nguyen Thi Thu, Trang, Do Thi, Huan, Nguyen Van, Anh, Phan Thi Lan, Tai, Bui Huu, Nhiem, Nguyen Xuan, Hung, Nguyen The, Kiem, Phan Van
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.11.2021
Subjects
Dregea volubilis
drevoluoside
pregnane glycoside
α-amylase
α-glucosidase
drevoluoside
pregnane glycoside
α-glucosidase
α-amylase
Dregea volubilis
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Summary:Three new pregnane glycosides, drevoluosides O-Q (1-3) along with five known volubiloside C (4), dreageoside A11 (5), 17β-marsdenin (6), stavaroside H (7), and hoyacarnoside G (8) were isolated from the methanol extract of the Dregea volubilis leaves. Their structures were elucidated by chemical and spectroscopic methods. Compounds 6-8 showed significant anti α-glucosidase activity with the inhibitory percentages ranging from 32.6 to 47.1% at the concentration of 200 μM. Compound 3 showed significant inhibitory α-amylase activity with IC 50 value of 51.3 ± 2.1 μM.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1749615