A2E, a byproduct of the visual cycle

A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the...

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Published inVision research (Oxford) Vol. 43; no. 28; pp. 2983 - 2990
Main Authors Sparrow, Janet R., Fishkin, Nathan, Zhou, Jilin, Cai, Bolin, Jang, Young P., Krane, Sonja, Itagaki, Yasuhiro, Nakanishi, Koji
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2003
Subjects
Aging
Atrophy
Atrophy - metabolism
Humans
Light - adverse effects
Lipofuscin
Lipofuscin - metabolism
Macular Degeneration - metabolism
Pigment Epithelium of Eye - metabolism
Pigment Epithelium of Eye - radiation effects
Pyridinium Compounds - metabolism
Retina - metabolism
Retina - pathology
Retinal pigment epithelium
Retinaldehyde - metabolism
Retinoids
Retinoids - metabolism
Vitamin A - metabolism
Atrophy
Aging
Lipofuscin
Retinoids
Retinal pigment epithelium
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Summary:A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0042-6989
1878-5646
DOI:10.1016/S0042-6989(03)00475-9