Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid

• Published in: Pharmaceutical biology Vol. 54; no. 10; pp. 2282 - 2287
• Main Authors: Sun, Jin-Yao, You, Cui-Yu, Dong, Kai, You, Hai-Sheng, Xing, Jian-Feng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.10.2016
• Subjects: Acetic Acid; Analgesics - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; Antioxidants - pharmacology; Carrageenan; Cotton Fiber; Dinoprostone - metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Edema - chemically induced; Edema - metabolism; Edema - prevention & control; Female; Granuloma, Foreign-Body - chemically induced; Granuloma, Foreign-Body - prevention & control; Hot Temperature; Hydroxyl Radical - chemistry; Illicium verum Hook.f; Indomethacin - pharmacology; Male; malondialdehyde; Malondialdehyde - metabolism; Mice, Inbred ICR; Pain - etiology; Pain - prevention & control; prostaglandin E2; Rats, Sprague-Dawley; Shikimic Acid - analogs & derivatives; Shikimic Acid - pharmacology; Superoxides - chemistry; Time Factors; xylene; Xylenes; xylene; Carrageenan; malondialdehyde; prostaglandin E2; Illicium verum Hook.f

Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, an...