Scleroderma renal crisis

Renal crisis occurs in patients who have systemic sclerosis with rapidly progressive diffuse cutaneous thickening early in their disease. SRC is characterized by malignant hypertension, hyperreninemia, azotemia, microangiopathic hemolytic anemia, and renal failure. SRC was almost uniformly fatal, bu...

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Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 29; no. 2; p. 315
Main Author Steen, Virginia D
Format Journal Article
LanguageEnglish
Published United States 01.05.2003
Subjects
Acute Kidney Injury - etiology
Acute Kidney Injury - pathology
Acute Kidney Injury - therapy
Humans
Scleroderma, Systemic - complications
Scleroderma, Systemic - pathology
Scleroderma, Systemic - therapy
Treatment Outcome
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Summary:Renal crisis occurs in patients who have systemic sclerosis with rapidly progressive diffuse cutaneous thickening early in their disease. SRC is characterized by malignant hypertension, hyperreninemia, azotemia, microangiopathic hemolytic anemia, and renal failure. SRC was almost uniformly fatal, but in most cases it can now be successfully treated with ACE inhibitors. This therapy has improved survival, reduced the requirement for dialysis, and often allowed for the discontinuation of dialysis 6 to 18 months later. Prompt diagnosis and early, aggressive initiation of therapy with ACE inhibitors will result in the most optimal outcome.
ISSN:0889-857X
DOI:10.1016/S0889-857X(03)00016-4