Gastrointestinal stromal tumor of the stomach:How to manage?

Gastrointestinal stromal tumor (GIST) is one of the most common malignant mesenchymal tumors of the stomach. Prognosis of this disease is related to tumor size and mitotic activity and early diagnosis is the only way to improve it.Diagnosis of GIST always requires histological and immunohistochemica...

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Published inWorld journal of gastrointestinal endoscopy Vol. 2; no. 8; pp. 271 - 277
Main Authors Akahoshi, Kazuya, Oya, Masafumi
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 16.08.2010
Subjects
Algorithm
aspiration
Endoscopic
endoscopy
Fine
Gastrointestinal
needle
stromal
tumor
ultrasound
Gastrointestinal endoscopy
Algorithm
Endoscopic ultrasound
Fine needle aspiration
Gastrointestinal stromal tumor
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Summary:Gastrointestinal stromal tumor (GIST) is one of the most common malignant mesenchymal tumors of the stomach. Prognosis of this disease is related to tumor size and mitotic activity and early diagnosis is the only way to improve it.Diagnosis of GIST always requires histological and immunohistochemical confirmation as no imaging modalities can diagnose it conclusively.Endoscopic forceps biopsy results are frequently negative. Endoscopic ultrasound-guided fine needle asp- iration (EUS-FNA) is a technique which allows tissue samples to be obtained with minimal risks and is accurate in the diagnosis of GIST. From the point of view of the endoscopist, aggressive use of EUS-FNA is the only promising way to allow early diagnosis and early treatment of this disease.
Bibliography:Kazuya Akahoshi,Department of Gastroenterology,Aso Iizuka Hospital,Iizuka 820-8505,Japan Masafumi Oya,Department of Pathology,Aso Iizuka Hospital,Iizuka 820-8505,Japan
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Author contributions: Akahoshi K performed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and wrote the paper; and Oya M performed immunohistological analysis of EUS-FNA specimens.
Correspondence to: Kazuya Akahoshi, MD, PhD, Department of Gastroenterology, Aso Iizuka Hospital, 3-83 Yoshio Town, Iizuka 820-8505, Japan. kakahoshi2@aol.com
ISSN:1948-5190
1948-5190
DOI:10.4253/wjge.v2.i8.271