Randomised controlled trial of single-dose azithromycin in treatment of trachoma

• Published in: The Lancet (British edition) Vol. 342; no. 8869; pp. 453 - 456
• Main Authors: Bailey, R.L., Arullendran, P., Mabey, D.C.W., Whittle, H.C.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 21.08.1993; Lancet; Elsevier Limited
• Subjects: Administration, Oral; Adolescent; Adult; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antigens, Bacterial - analysis; Azithromycin; Biological and medical sciences; Child; Child, Preschool; Chlamydia trachomatis - immunology; Drug therapy; Erythromycin - administration & dosage; Erythromycin - adverse effects; Erythromycin - analogs & derivatives; Erythromycin - therapeutic use; Eye; Eyes & eyesight; Female; Follow-Up Studies; Humans; Infant; Infections; Male; Medical research; Medical sciences; Middle Aged; Ointments; Patient Compliance; Pharmacology. Drug treatments; Public health; Recurrence; Sexually transmitted diseases; Single-Blind Method; STD; Tetracycline - administration & dosage; Tetracycline - adverse effects; Tetracycline - therapeutic use; Trachoma - drug therapy; Trachoma - microbiology; Human; Chlamydiaceae; Oral administration; Trachoma; Chlamydia trachomatis; Infection; Eye disease; Antibiotic; Chemotherapy; Treatment; Bacteriosis; Chlamydiales; Bacteria; Chlamydiosis; Comparative study; Comparative Studies; Biology; Infections; Research Methodology; English Speaking Africa; Chlamydia; Gambia; Rural Population; Population Characteristics; Reproductive Tract Infections; Population; Research Report; Physiology; Demographic Factors; Africa; Diseases; Studies; Western Africa; Sexually Transmitted Diseases; Follow-up Studies; Developing Countries; Drugs > therapeutic use; Africa South Of The Sahara; Ophthalmological Effects

Blindness due to trachoma is a serious public health issue world wide. The currently recommended treatment of active trachoma with repeated doses of tetracycline eye ointment has many disadvantages. The new azalide antibiotic azithromycin is effective as a single oral dose in the chemotherapy of gen...