Randomised controlled trial of single-dose azithromycin in treatment of trachoma

• Published in: The Lancet (British edition) Vol. 342; no. 8869; pp. 453 - 456
• Main Authors: Bailey, R.L., Arullendran, P., Mabey, D.C.W., Whittle, H.C.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 21.08.1993; Lancet; Elsevier Limited
• Subjects: Administration, Oral; Adolescent; Adult; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antigens, Bacterial - analysis; Azithromycin; Biological and medical sciences; Child; Child, Preschool; Chlamydia trachomatis - immunology; Drug therapy; Erythromycin - administration & dosage; Erythromycin - adverse effects; Erythromycin - analogs & derivatives; Erythromycin - therapeutic use; Eye; Eyes & eyesight; Female; Follow-Up Studies; Humans; Infant; Infections; Male; Medical research; Medical sciences; Middle Aged; Ointments; Patient Compliance; Pharmacology. Drug treatments; Public health; Recurrence; Sexually transmitted diseases; Single-Blind Method; STD; Tetracycline - administration & dosage; Tetracycline - adverse effects; Tetracycline - therapeutic use; Trachoma - drug therapy; Trachoma - microbiology; Human; Chlamydiaceae; Oral administration; Trachoma; Chlamydia trachomatis; Infection; Eye disease; Antibiotic; Chemotherapy; Treatment; Bacteriosis; Chlamydiales; Bacteria; Chlamydiosis; Comparative study; Comparative Studies; Biology; Infections; Research Methodology; English Speaking Africa; Chlamydia; Gambia; Rural Population; Population Characteristics; Reproductive Tract Infections; Population; Research Report; Physiology; Demographic Factors; Africa; Diseases; Studies; Western Africa; Sexually Transmitted Diseases; Follow-up Studies; Developing Countries; Drugs > therapeutic use; Africa South Of The Sahara; Ophthalmological Effects
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/0140-6736(93)91591-9

Blindness due to trachoma is a serious public health issue world wide. The currently recommended treatment of active trachoma with repeated doses of tetracycline eye ointment has many disadvantages. The new azalide antibiotic azithromycin is effective as a single oral dose in the chemotherapy of genital Chlamydia trachomatis infections, and we have assessed its efficacy for trachoma treatment. We carried out a randomised single-blind comparison of azithromycin (a single oral dose of 20 mg/kg) with conventional treatment (6 weeks of topical tetracycline plus erythromycin for severe cases) in two villages with endemic trachoma in The Gambia. The patients were followed up for 26 weeks from the start of treatment by an observer unaware of treatment allocation. By 6 months' follow-up, trachoma had resolved in 76 (78%) of 97 subjects who received azithromycin compared with 70 (72%) of 97 who were treated conventionally (95% Cl for difference - 6% to 18%). Compliance with both treatments was good, but that for conventional treatment could probably not be achieved outside the research setting. There were no significant differences in treatment effect, baseline characteristics, or re-emergent disease between the treatment groups. Azithromycin was well tolerated. As a systemic treatment effective in a single dose it has important potential for trachoma control.