Evolution of angiotensin II-induced catecholamine release

The interaction between angiotensin II (ANG II) and catecholamines was examined in nonmammalian vertebrates. ANG II challenge caused a significant pressor response in representatives of the seven vertebrate classes. Additionally, plasma levels of both epinephrine and norepinephrine increased followi...

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Bibliographic Details
Published inThe American journal of physiology Vol. 243; no. 1; p. R65
Main Authors Carroll, R G, Opdyke, D F
Format Journal Article
LanguageEnglish
Published United States 01.07.1982
Subjects
Angiotensin II - pharmacology
Animals
Chickens
Epinephrine - blood
Epinephrine - secretion
Fishes
Hagfishes
Kinetics
Norepinephrine - blood
Norepinephrine - secretion
Phentolamine - pharmacology
Rana catesbeiana
Rats
Rats, Inbred Strains
Species Specificity
Turtles
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Summary:The interaction between angiotensin II (ANG II) and catecholamines was examined in nonmammalian vertebrates. ANG II challenge caused a significant pressor response in representatives of the seven vertebrate classes. Additionally, plasma levels of both epinephrine and norepinephrine increased following intravascular ANG II injection in the conscious lumpfish, bullfrog, and turtle, and the anesthetized chicken. Phentolamine pretreatment totally abolished ANG II pressor action in the hagfish and chicken and diminished the ANG II pressor response in other classes of vertebrates. The ability of ANG II to release catecholamines appears to be a phylogenetically ancient interaction and indicates that catecholamines may play an important role in the physiological expression of ANG II action in lower vertebrates.
ISSN:0002-9513
DOI:10.1152/ajpregu.1982.243.1.R65