Molecular processes in the streptokinase thrombolytic therapy

The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectoriz...

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Published inJournal of enzyme inhibition and medicinal chemistry Vol. 31; no. 6; pp. 1411 - 1414
Main Authors Capitanescu, Cristian, Macovei Oprescu, Anca Monica, Ionita, Dan, Dinca, Gabi Valeriu, Turculet, Claudiu, Manole, Gheorghe, Macovei, Radu Alexandru
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.11.2016
Subjects
Antiplasmin
Humans
magnetic nanoparticle
streptokinase
Streptokinase - therapeutic use
Thrombolytic Therapy
thrombus
streptokinase
magnetic nanoparticle
thrombus
Antiplasmin
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Summary:The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectorized nanoparticles streptokinase and human blood thrombus. The experimental data confirm the maximum 83% thrombus lyses whenever increase streptokinase concentration. It is very probable to happen because of the presence of high concentration of antiplasmin in the blood that neutralizes around half of the thrombolytic potential of the sanguine plasminogen. The experiment shows also that only free serum plasminogen are available for streptokinase action in order to generate plasmin.
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ISSN:1475-6366
1475-6374
DOI:10.3109/14756366.2016.1142985