Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 17; no. 8; pp. 1930 - 1936
• Main Authors: ZICK, Suzanna M, DJURIC, Zora, RUFFIN, Mack T, LITZINGER, Amie J, NORMOLLE, Daniel P, ALRAWI, Sara, FENG, Meihua Rose, BRENNER, Dean E
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2008
• Subjects: Adult; Area Under Curve; Biological and medical sciences; Catechols - administration & dosage; Catechols - metabolism; Catechols - pharmacokinetics; Chemoprevention; Clinical trial; Fatty Alcohols - administration & dosage; Fatty Alcohols - metabolism; Fatty Alcohols - pharmacokinetics; Female; Ginger; Gingerols; Humans; Male; Medical sciences; Metabolism; Middle Aged; Pharmacokinetics; Shogaol; Tumors; Human; Cancerology; Healthy subject; Conjugated compound; Pharmacokinetics; Metabolite

Background: Ginger shows promising anticancer properties. No research has examined the pharmacokinetics of the ginger constituents 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in humans. We conducted a clinical trial with 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, examining the pharma...