Repetitive Sequence Stability in Embryonic Stem Cells

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8819
• Main Authors: Shi, Guang, Pang, Qianwen, Lin, Zhancheng, Zhang, Xinyi, Huang, Kaimeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.08.2024; MDPI
• Subjects: Animals; Chromatin - genetics; Chromatin - metabolism; DNA Damage; DNA methylation; DNA Repair; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Enzymes; Epigenesis, Genetic; Epigenetics; Gene expression; Genomes; Genomic Instability; Humans; Proteins; Repetitive Sequences, Nucleic Acid - genetics; Review; Roles; Satellites; Stem cells; repetitive sequences; epigenetic regulation; DNA damage; embryonic stem cells

Repetitive sequences play an indispensable role in gene expression, transcriptional regulation, and chromosome arrangements through trans and cis regulation. In this review, focusing on recent advances, we summarize the epigenetic regulatory mechanisms of repetitive sequences in embryonic stem cells...