Repetitive Sequence Stability in Embryonic Stem Cells

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8819
• Main Authors: Shi, Guang, Pang, Qianwen, Lin, Zhancheng, Zhang, Xinyi, Huang, Kaimeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.08.2024; MDPI
• Subjects: Animals; Chromatin - genetics; Chromatin - metabolism; DNA Damage; DNA methylation; DNA Repair; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Enzymes; Epigenesis, Genetic; Epigenetics; Gene expression; Genomes; Genomic Instability; Humans; Proteins; Repetitive Sequences, Nucleic Acid - genetics; Review; Roles; Satellites; Stem cells; repetitive sequences; epigenetic regulation; DNA damage; embryonic stem cells
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25168819

Repetitive sequences play an indispensable role in gene expression, transcriptional regulation, and chromosome arrangements through trans and cis regulation. In this review, focusing on recent advances, we summarize the epigenetic regulatory mechanisms of repetitive sequences in embryonic stem cells. We aim to bridge the knowledge gap by discussing DNA damage repair pathway choices on repetitive sequences and summarizing the significance of chromatin organization on repetitive sequences in response to DNA damage. By consolidating these insights, we underscore the critical relationship between the stability of repetitive sequences and early embryonic development, seeking to provide a deeper understanding of repetitive sequence stability and setting the stage for further research and potential therapeutic strategies in developmental biology and regenerative medicine.