Complement receptor mediates enhanced flavivirus replication in macrophages

Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monocl...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 158; no. 1; pp. 258 - 263
Main Authors Cardosa, M J, Porterfield, J S, Gordon, S
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.07.1983
Subjects
Animals
Antibodies, Monoclonal
Antibodies, Viral - physiology
Cell Line
complement component C3
flavivirus
Immunoglobulin M - physiology
macrophages
Macrophages - immunology
Macrophages - microbiology
Mice
receptors
Receptors, Complement - physiology
Virus Replication
West Nile virus - immunology
West Nile virus - physiology
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Summary:Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
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SourceType-Scholarly Journals-1
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ISSN:0022-1007
1540-9538
DOI:10.1084/jem.158.1.258