Capillary NMDA receptors regulate blood-brain barrier function and breakdown

Polyamines and their regulatory synthetic enzyme ornithine decarboxylase (ODC) have been implicated in blood-brain barrier (BBB) breakdown following cryogenic injury. ODC activation and BBB breakdown are prevented by MK-801, indicating involvement of NMDA receptors. Studies in isolated rat cerebral...

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Bibliographic Details
Published inBrain research Vol. 588; no. 2; p. 297
Main Authors Koenig, H, Trout, J J, Goldstone, A D, Lu, C Y
Format Journal Article
LanguageEnglish
Published Netherlands 21.08.1992
Subjects
Animals
Blood-Brain Barrier - physiology
Brain Edema - metabolism
Capillaries - physiology
Deoxyglucose - metabolism
Female
Horseradish Peroxidase
In Vitro Techniques
Ornithine Decarboxylase - metabolism
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Glutamate - metabolism
Receptors, N-Methyl-D-Aspartate - physiology
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Summary:Polyamines and their regulatory synthetic enzyme ornithine decarboxylase (ODC) have been implicated in blood-brain barrier (BBB) breakdown following cryogenic injury. ODC activation and BBB breakdown are prevented by MK-801, indicating involvement of NMDA receptors. Studies in isolated rat cerebral capillaries supports the presence of NMDA receptors linked to ODC. NMDA (1-50 microM) stimulated capillary uptake of horseradish peroxidase, 2-deoxy-[14C]glucose, and 45 Ca in a receptor-, concentration-, polyamine- and Ca(2+)-dependent manner. We suggest that NMDA receptors may couple capillary transport of nutrients to glutamate-mediated neuronal excitation, and when overestimated disrupt normal BBB function.
ISSN:0006-8993
DOI:10.1016/0006-8993(92)91589-7