Ciliary Functional Analysis in Chronic Rhinosinusitis with Polyps after Multimodal Intervention: Oral Corticosteroid, Functional Endoscopic Sinus Surgery, and Omalizumab Injection

In her late 50 s, a woman with a medical history of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) experienced a relapse of nasal polyps, significantly impacting her breathing and sense of smell. She underwent a multifaceted treatment approach, including oral corticos...

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Published inCase reports in otolaryngology Vol. 2024; pp. 5559001 - 4
Main Authors Benchimol, Lionel, Bouchain, Olivier, Bricmont, Noemie, Bonhiver, Romane, Kempeneers, Celine, Lefebvre, Philippe, Poirrier, Anne-Lise
Format Journal Article Web Resource
LanguageEnglish
Published United States Hindawi 14.05.2024
Hindawi Limited
Subjects
Asthma
Case Report
Case reports
Chronic illnesses
Clinical outcomes
Cytokines
Dyskinesia
Endoscopy
Human health sciences
Inflammation
Oto-rhino-laryngologie
Otolaryngology
Outpatient care facilities
Patients
Polyps
Sciences de la santé humaine
Sinuses
Steroids
Surgery
Surgical techniques
United States > US
Germany
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Summary:In her late 50 s, a woman with a medical history of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) experienced a relapse of nasal polyps, significantly impacting her breathing and sense of smell. She underwent a multifaceted treatment approach, including oral corticosteroids, functional endoscopic sinus surgery, and omalizumab injections. Digital high-speed videomicroscopy (DHSV) revealed only partial improvement in ciliary beat pattern and ciliary beat frequency with oral corticosteroid treatment, while significant improvement in these ciliary parameters was observed with omalizumab injections. Furthermore, administration of omalizumab resulted in a decrease in her SNOT-22 (Sinonasal Outcome Test 22) score. Notably, this case report represents the first study investigating ciliary function using DHSV in a patient treated with omalizumab.
Bibliography:Academic Editor: Rong-San Jiang
ISSN:2090-6765
2090-6773
2090-6773
DOI:10.1155/2024/5559001