Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- a...

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Bibliographic Details
Published inSkin pharmacology and physiology Vol. 33; no. 5; pp. 261 - 269
Main Authors Lengert, Ekaterina V., Talnikova, Ekaterina E., Tuchin, Valery V., Svenskaya, Yulia I.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.11.2020
Subjects
Antifungal agents
Design and construction
Dosage and administration
Drug therapy
Mycoses
Nanotechnology
Review Article
Transdermal medication
Russia
Transdermal drug delivery
Dermatophytes
Antimycotics
Antifungal agents
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Summary:Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area.
ISSN:1660-5527
1660-5535
DOI:10.1159/000511038