Approaches to Improving the Selectivity of Nanozymes

• Published in: Advanced materials (Weinheim) Vol. 36; no. 10; pp. e2211288 - n/a
• Main Authors: Somerville, Samuel V., Li, Qinyu, Wordsworth, Johanna, Jamali, Sina, Eskandarian, Mohammad Reza, Tilley, Richard D., Gooding, J. Justin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2024
• Subjects: Active control; active sites; artificial enzymes; Catalysis; Catalytic Domain; confinement; Enzymes; Metal Nanoparticles - chemistry; Nanoparticles; nanozymes; Selectivity; substrate channeling; Substrates; active sites; nanozymes; substrate channeling; confinement; artificial enzymes
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.202211288

Nanozymes mimic enzymes and that includes their selectivity. To achieve selectivity, significant inspiration for nanoparticle design can come from the geometric and molecular features that make enzymes selective catalysts. The two central features enzymes use are control over the arrangement of atoms in the active site and the placing of the active site down a nanoconfined substrate channel. The implementation of enzyme‐inspired features has already been shown to both improve activity and selectivity of nanoparticles for a variety of catalytic and sensing applications. The tuning and control of active sites on metal nanoparticle surfaces ranges from simply changing the composition of the surface metal to sophisticated approaches such as the immobilization of single atoms on a metal substrate. Molecular frameworks provide a powerful platform for the implementation of isolated and discrete active sites while unique diffusional environments further improve selectivity. The implementation of nanoconfined substrate channels around these highly controlled active sites offers further ability to control selectivity through altering the solution environment and transport of reactants and products. Implementing these strategies together offers a unique opportunity to improve nanozyme selectivity in both sensing and catalysis. Nanozymes must be selective if they are to replace enzymes in sensing or catalysis. Mimicking enzymatic active sites and nanoconfined substrate channels provides an avenue to improving the selectivity of nanozymes. However, a purely biomimetic approach to nanozyme design limits the design of enzyme mimics. Therefore, designers endeavor to utilize all synthetic methods to make more selective nanozymes.