Bioorthogonally Assisted Phototherapy: Recent Advances and Prospects

Photoresponsive materials offer excellent spatiotemporal control over biological processes and the emerging phototherapeutic methods are expected to have significant effects on targeted cancer therapies. Recent examples show that combination of photoactivatable approaches with bioorthogonal chemistr...

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Published inAngewandte Chemie International Edition Vol. 62; no. 33; pp. e202303198 - n/a
Main Authors Kozma, Eszter, Bojtár, Márton, Kele, Péter
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 14.08.2023
EditionInternational ed. in English
Subjects
Activatable
Biological activity
Bioorthogonal
Cancer
Cancer therapies
Humans
Neoplasms - therapy
Phototherapy
Targeting
Theranostic Nanomedicine
Tumors
Bioorthogonal
Targeting
Activatable
Cancer
Phototherapy
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Summary:Photoresponsive materials offer excellent spatiotemporal control over biological processes and the emerging phototherapeutic methods are expected to have significant effects on targeted cancer therapies. Recent examples show that combination of photoactivatable approaches with bioorthogonal chemistry enhances the precision of targeted phototherapies and profound implications are foreseen particularly in the treatment of disperse/diffuse tumors. The extra level of on‐target selectivity and improved spatial/temporal control considerably intensified related bioorthogonally assisted phototherapy research. The anticipated growth of further developments in the field justifies the timeliness of a brief summary of the state of the art. Phototherapeutic approaches combined with bioorthogonal chemistry are expected to significantly improve the spatiotemporal precision of targeted therapies. As a result, related bioorthogonally assisted phototherapy research has recently intensified. This minireview briefly discusses the latest developments in the state of the art.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202303198