Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity
The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged li...
Saved in:
Published in | Macromolecular bioscience Vol. 12; no. 9; pp. 1181 - 1189 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.09.2012
WILEY‐VCH Verlag Wiley-VCH |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane‐destroying efficacy of the antimicrobial polymers.
The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests. |
---|---|
Bibliography: | European Commission - No. CP-TP 228490-2 istex:03A07EF981A5BD54D9854BB98063A6F4A58AE173 ark:/67375/WNG-B4WXTT7P-5 ArticleID:MABI201200078 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1616-5187 1616-5195 |
DOI: | 10.1002/mabi.201200078 |