Fetal biometry of skeletal dysplasias: a multicentric study

Twenty-three diagnostic centers worldwide contributed 127 cases of 17 skeletal dysplasias. Discriminant analysis showed that the femur length was the best biometric parameter to distinguish among the five most common disorders in this series (thanatophoric dysplasia, osteogenesis imperfecta type II,...

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Bibliographic Details
Published inJournal of ultrasound in medicine Vol. 13; no. 12; p. 977
Main Authors Goncalves, L, Jeanty, P
Format Journal Article
LanguageEnglish
Published England 01.12.1994
Subjects
Bone Diseases, Developmental - diagnosis
Bone Diseases, Developmental - diagnostic imaging
Crown-Rump Length
Diagnosis, Differential
Female
Fetal Diseases - diagnosis
Fetal Diseases - diagnostic imaging
Humans
Infant, Newborn
Pregnancy
Ultrasonography, Prenatal
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Summary:Twenty-three diagnostic centers worldwide contributed 127 cases of 17 skeletal dysplasias. Discriminant analysis showed that the femur length was the best biometric parameter to distinguish among the five most common disorders in this series (thanatophoric dysplasia, osteogenesis imperfecta type II, achondrogenesis, achondroplasia and hypochondroplasia). Fifty-four percent of fetuses with femur length below 30% of the mean for gestational age had achondrogenesis. Seventy-eight percent of measurements between 40 and 60% of the mean for gestational age represented either thanatophoric dysplasia or osteogenesis imperfecta type II. Fetuses who had over 80% of the mean for gestational age had predominantly hypochondroplasia, achondroplasia, and osteogenesis imperfecta type III.
ISSN:0278-4297
1550-9613
DOI:10.7863/jum.1994.13.12.977