Cardiac Metabolism in Experimental Ventricular Fibrillation

The cardiac metabolism of the fibrillating left ventricle of the dog heart with and without maintenance of left coronary artery inflow was investigated. During ventricular fibrillation without maintenance of coronary flow, myocardial adenosine triphosphate and glycogen fell progressively, and in vit...

Full description

Saved in:
Bibliographic Details
Published inCirculation research Vol. 2; no. 6; pp. 573 - 578
Main Authors Paul, M H, Theilen, E O, Gregg, D E, Marsh, J B, Casten, G G
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 01.11.1954
Subjects
Humans
Old Medline
Ventricular Fibrillation
VENTRICULAR FIBRILLATION/experimental
Online AccessGet full text

Cover

More Information
Summary:The cardiac metabolism of the fibrillating left ventricle of the dog heart with and without maintenance of left coronary artery inflow was investigated. During ventricular fibrillation without maintenance of coronary flow, myocardial adenosine triphosphate and glycogen fell progressively, and in vitro oxygen consumption of biopsied tissue initially increased, but with adequate coronary perfusion these elements were maintained. With reinstitution of coronary flow after 30 to 40 minutes of fibrillation without flow, resynthesis of high energy phosphate occurred. The coronary artery-coronary sinus oxygen difference and left ventricular oxygen usage both decreased in the perfused fibrillating heart as compared with the values in the beating heart.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.2.6.573