Structural Remodeling of Cocaine: Design and Synthesis of Trisubstituted Cyclopropanes as Selective Serotonin Reuptake Inhibitors

Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other...

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Published inChemMedChem Vol. 1; no. 1; pp. 58 - 65
Main Authors Kozikowski, Alan P., Zhao, Lianyun, Zhang, Ao, Wang, Cheng Z., Flippen-Anderson, Judith, Johnson, Kenneth M.
Format Journal Article
LanguageEnglish
German
Published Weinheim WILEY-VCH Verlag 16.01.2006
WILEY‐VCH Verlag
Subjects
cocaine
Cocaine - chemistry
Cocaine - pharmacology
cyclopropane
Cyclopropanes - chemistry
Models, Molecular
Molecular Structure
monoamine inhibitors
neurochemistry
neurotransmitters
Serotonin Uptake Inhibitors - chemistry
Serotonin Uptake Inhibitors - pharmacology
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Summary:Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.
Bibliography:istex:32A39A411187947629E71B9F2132ED2EEFEE3EF2
ArticleID:CMDC200500016
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200500016