Synthesis and hydrolysis study of polyacrylates containing 2′,5-dichloro-4′-nitrosalicylanilide

• Published in: Journal of applied polymer science Vol. 66; no. 1; pp. 29 - 33
• Main Authors: Yang, Y. S., Qi, G. R., Qian, J. W., Yang, S. L.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 03.10.1997; Wiley
• Subjects: 2′,5‐dichloro‐4′‐nitrosalicylanilide; 5-dichloro-4′-nitrosalicylanilide; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Applied sciences; Biological and medical sciences; Exact sciences and technology; hydrolysis; Medical sciences; Organic polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; polyacrylates; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; synthesis; Anthelmintic; Control release polymer; Niclosamide; Drug carrier; Chemical degradation; Experimental study; Acrylamide derivative polymer; Hydrolysis; Methacrylamide derivative polymer; Free radical polymerization; Preparation; Parasiticid; Kinetics; Release
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/(SICI)1097-4628(19971003)66:1<29::AID-APP4>3.0.CO;2-Q

Monomers (meth)acryloyloxy‐2′,5‐dichloro‐4′‐nitrosalicylanilide have been synthesized by treating 2′,5‐dichloro‐4′‐nitrosalicylanilide (niclosamide) with acryloyl or methacryloyl chloride, and polymerized by free radical polymerization to give a polymer containing chemically bonded niclosamide. The structure of monomer and polymer were confirmed by IR, UV, and elemental analysis. Hydrolysis data of polymer in different media indicated that the hydrolysis rates of polymer were strongly dependent on the nature of the polymer structure and the hydrolyzing medium. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 29–33, 1997