Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer‐Based Nanocomposites

• Published in: Advanced materials (Weinheim) Vol. 33; no. 2; pp. e2003883 - n/a
• Main Authors: Alsharabasy, Amir M., Pandit, Abhay, Farràs, Pau
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2021
• Subjects: Biomimetic Materials - chemistry; Biomimetics; biosensing; Biosensing Techniques - methods; Coordination polymers; Dimerization; Enzymes; hemin; Hemin - chemistry; hemin aggregation; Materials science; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Nanocomposites; Nanocomposites - chemistry; Oxidation; Polymers - chemistry; Proteins; coordination polymers; biosensing; hemin aggregation; hemin; metal-organic frameworks
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202003883

The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the field due to the problems associated with the extraction, purification, and storage of enzymes in sensing applications. Of these mimetics, hemin/coordination polymer‐based nanocomposites, mainly hemin/metal–organic frameworks (MOF), have been developed for various biosensing applications because of the unique properties of each component, while trying to mimic the normal biological functions of heme within the protein milieu of enzymes. This critical review first discusses the different catalytic functions of heme in the body in the form of enzyme/protein structures. The properties of hemin dimerization are then elucidated with the supposed models of hemin oxidation. After that, the progress in the fabrication of hemin/MOF nanocomposites for the sensing of diverse biological molecules is discussed. Finally, the challenges in developing this type of composites are examined as well as possible proposals for future directions to enhance the sensing performance in this field further. By combining the properties of hemin and porous coordination polymers into novel nanocomposites, different types of sensors can be generated for testing the concentrations of different biological molecules. These biosensors are based on electrochemical, chemiluminescent, or colorimetric techniques, and have excellent detection limits and stability.