Chemical Constituents of the Deep‐Sea‐Derived Fungus Cladosporium oxysporum 170103 and Their Antibacterial Effects

• Published in: Chemistry & biodiversity Vol. 19; no. 12; pp. e202200963 - n/a
• Main Authors: Xie, Ming‐Min, Jiang, Jia‐Yang, Zou, Zheng‐Biao, Xu, Lin, Zhang, Yong, Wang, Chao‐Feng, Liu, Cheng‐Bin, Yan, Qing‐Xiang, Liu, Zhu, Yang, Xian‐Wen
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.12.2022
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Bacteria; Cell size; Cladosporium - chemistry; Cladosporium oxysporum; deep-sea; Ergosterol; Fungi; fungus; Metabolites; Minimum inhibitory concentration; Molecular Structure; NMR; Nuclear magnetic resonance; Secondary metabolites; secopatulolides; Vibrio; Vibrio parahemolyticus; deep-sea; Cladosporium oxysporum; Vibrio parahemolyticus; fungus; secopatulolides
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202200963

The Cladosporium fungi, one of the largest genera of dematiaceous hyphomycetes, could produce various bioactive secondary metabolites. From the AcOEt‐soluble extract of Cladosporium oxysporum 170103, three new secopatulolides (1–3) and thirteen known compounds (4–16) were obtained. Their structures were established by detailed analysis of the NMR and HR‐ESI‐MS data. All sixteen compounds were tested for antibacterial activity against Vibrio parahemolyticus, ergosterol (10) presented moderate effect with the minimum inhibitory concentration (MIC) of 32 μM. It can destruct the membrane integrity of Vibrio parahemolyticus to change the cell shape.