Transplantation tolerance: The concept and its applicability

• Published in: Pediatric transplantation Vol. 3; no. 3; pp. 181 - 192
• Main Authors: Dong, Victor M., Womer, Karl L., Sayegh, Mohamed H.
• Format: Journal Article
• Language: English
• Published: Copenhagen, Denmark Munksgaard International Publishers 01.08.1999; Blackwell
• Subjects: allorecognition; Animals; Antigens, CD - immunology; Biological and medical sciences; Bone Marrow Transplantation - immunology; costimulatory blockade; Graft Rejection - immunology; Graft Survival - immunology; Graft vs Host Disease - immunology; Humans; Immune Tolerance - immunology; Immunity, Cellular; Immunopathology; Immunosuppression; Immunotherapy (general aspects); Kidney Transplantation - immunology; Major Histocompatibility Complex - immunology; Medical sciences; Mice; Mice, Knockout; Rats; rejection; Self Tolerance - immunology; T-Lymphocytes - immunology; tolerance; transplantation; Transplantation Chimera - immunology; Transplantation Immunology; Human; Surgery; Immune tolerance; Transplantation; Review; Homotransplantation; Mechanism
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1034/j.1399-3046.1999.00042.x

: Recent advances have enabled researchers to induce tolerance in animal transplant models. Although it has been relatively easy to do so in rodents, it has been much more difficult to translate such strategies into primates. Understanding the cellular and molecular mechanisms of the alloimmune response has prompted the development of novel strategies that may obviate the need for immunosuppression in humans. Mechanisms of tolerance and promising new therapies, as well as the inherent difficulties in bringing them into clinical practice, are reviewed.