Nanoparticle-based targeted drug delivery

• Published in: Experimental and molecular pathology Vol. 86; no. 3; pp. 215 - 223
• Main Authors: Singh, Rajesh, Lillard, James W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2009
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cancer therapy; Dendrimers; Drug delivery; Drug Delivery Systems - methods; Humans; Hydrogels; Liposomes; Micelles; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanotechnology; Neoplasms - drug therapy; Quantum Dots; XPclad © nanoparticles; BBB; PLA; MRI; CPT; EPR; PLG; Drug delivery; Nanoparticles; MPS; PspA; GBM; MDR; TLR; SWCNT; Mabs; PEO-PPO; C32; DT-A; Quantum dots; DOX; SSM; Tween 80; PCA; XPclad © nanoparticles; PEG; PLGA; GCS; Cancer therapy; PEO-PCL; C60; HER2
• ISSN: 0014-4800; 1096-0945; 1096-0945
• DOI: 10.1016/j.yexmp.2008.12.004

Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the “nanometer” size range. These nano-sized objects, e.g., “nanoparticles”, take on novel properties and functions that differ markedly from those seen from items made of identical materials. The small size, customized surface, improved solubility, and multi-functionality of nanoparticles will continue to open many doors and create new biomedical applications. Indeed, the novel properties of nanoparticles offer the ability to interact with complex cellular functions in new ways. This rapidly growing field requires cross-disciplinary research and provides opportunities to design and develop multifunctional devices that can target, diagnose, and treat devastating diseases such as cancer. This article presents an overview of nanotechnology for the biologist and discusses the attributes of our novel XPclad © nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.