Efficacy of Antibiotic-Coated Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Rabbits

• Published in: The Journal of infectious diseases Vol. 167; no. 1; pp. 98 - 106
• Main Authors: Sherertz, Robert J., Carruth, William A., Hampton, A. A., Byron, M. Parke, Solomon, Donald D.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.01.1993; University of Chicago Press
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiinfectives; Biological and medical sciences; Catheterization - adverse effects; Catheters; Catheters, Indwelling; Central venous catheterization; Chlorhexidine - pharmacology; Ciprofloxacin - pharmacology; Clindamycin - pharmacology; Coatings; Dicloxacillin - pharmacology; Fusidic Acid - pharmacology; Half lives; Half-Life; Heparin; Indwelling catheters; Infections; Inoculation; Major Articles; Medical sciences; Pharmacology. Drug treatments; Rabbits; Staphylococcal Infections - prevention & control; Staphylococcus aureus; Intravenous administration; Catheter; Rabbit; Lagomorpha; Experimental study; Infection; Prevention; Vertebrata; Antibiotic; Mammalia; Animal; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Coating; Staphylococcal infection; Comparative study; Staphylococcus aureus

Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better t...