Efficacy of Antibiotic-Coated Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Rabbits
Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better t...
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| Published in | The Journal of infectious diseases Vol. 167; no. 1; pp. 98 - 106 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chicago, IL
The University of Chicago Press
01.01.1993
University of Chicago Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment t1/2, 16.8 h; second-compartment tl/2, 115.6 h. In a rabbit model, dicloxacillin, clindarnycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. |
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| AbstractList | Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment t1/2, 16.8 h; second-compartment tl/2, 115.6 h. In a rabbit model, dicloxacillin, clindarnycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment t1/2, 16.8 h; second-compartment t1/2, 115.6 h. In a rabbit model, dicloxacillin, clindamycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. The data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment t1/2, 16.8 h; second-compartment t1/2, 115.6 h. In a rabbit model, dicloxacillin, clindamycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment$t_{1/2}$, 16.8 h; second-compartment$t_{1/2}$, 115.6 h. In a rabbit model, dicloxacillin, clindamycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients. |
| Author | Byron, M. Parke Sherertz, Robert J. Carruth, William A. Hampton, A. A. Solomon, Donald D. |
| Author_xml | – sequence: 1 givenname: Robert J. surname: Sherertz fullname: Sherertz, Robert J. organization: Division of Infectious Diseases, Department of Medicine, Wake Forest Medical Center, Winston-Salem, North Carolina, Charleston, Dayton, Ohio – sequence: 2 givenname: William A. surname: Carruth fullname: Carruth, William A. organization: Division of Infectious Diseases, Department of Medicine, Wake Forest Medical Center, Winston-Salem, North Carolina, Charleston, Dayton, Ohio – sequence: 3 givenname: A. A. surname: Hampton fullname: Hampton, A. A. organization: Division of Infectious Diseases, Department of Medicine, Wake Forest Medical Center, Winston-Salem, North Carolina, Charleston, Dayton, Ohio – sequence: 4 givenname: M. Parke surname: Byron fullname: Byron, M. Parke organization: Division of Infectious Diseases, Department of Medicine, Wake Forest Medical Center, Winston-Salem, North Carolina, Charleston, Dayton, Ohio – sequence: 5 givenname: Donald D. surname: Solomon fullname: Solomon, Donald D. organization: Division of Infectious Diseases, Department of Medicine, Wake Forest Medical Center, Winston-Salem, North Carolina, Charleston, Dayton, Ohio |
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| Keywords | Intravenous administration Catheter Rabbit Lagomorpha Experimental study Infection Prevention Vertebrata Antibiotic Mammalia Animal Bacteriosis Bacteria Micrococcales Micrococcaceae Coating Staphylococcal infection Comparative study Staphylococcus aureus |
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| Notes | istex:512C39AADED511A8AF3FECDDD3B94F650378A378 Reprints or correspondence: Dr. Robert J. Sherertz, Division ofInfectious Diseases. Wake Forest Medical Center, Medical Center Blvd., WinstonSalem, NC 27157-1042. ark:/67375/HXZ-1H7BDNGP-L ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
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| SubjectTerms | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiinfectives Biological and medical sciences Catheterization - adverse effects Catheters Catheters, Indwelling Central venous catheterization Chlorhexidine - pharmacology Ciprofloxacin - pharmacology Clindamycin - pharmacology Coatings Dicloxacillin - pharmacology Fusidic Acid - pharmacology Half lives Half-Life Heparin Indwelling catheters Infections Inoculation Major Articles Medical sciences Pharmacology. Drug treatments Rabbits Staphylococcal Infections - prevention & control |
| Title | Efficacy of Antibiotic-Coated Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Rabbits |
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