Diacylglycerol Kinases: Emerging Downstream Regulators in Cell Signaling Systems

• Published in: Journal of biochemistry (Tokyo) Vol. 131; no. 5; pp. 629 - 633
• Main Authors: Kanoh, Hideo, Yamada, Keiko, Sakane, Fumio
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2002
• Subjects: alternative splicing; Alternative Splicing - genetics; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Conserved Sequence; diacylgcerol kinase; diacylglycerol; Diacylglycerol Kinase - genetics; Diacylglycerol Kinase - metabolism; Diacylglycerol Kinase - physiology; Diglycerides - metabolism; Isoenzymes - genetics; Isoenzymes - metabolism; Isoenzymes - physiology; phosphatidic acid; Phosphatidic Acids - metabolism; Phosphorylation; Protein Kinase C - metabolism; Receptors, Drug - metabolism; signal transduction; Signal Transduction - physiology; Tyrosine - metabolism
• ISSN: 0021-924X; 1756-2651
• DOI: 10.1093/oxfordjournals.jbchem.a003144

Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.