An Injectable Nanocomposite Hydrogel for Potential Application of Vascularization and Tissue Repair

• Published in: Annals of biomedical engineering Vol. 48; no. 5; pp. 1511 - 1523
• Main Authors: Ding, Yilei, Zhao, An-sha, Liu, Tianmei, Wang, Ya-nan, Gao, Yuan, Li, Jing-an, Yang, Ping
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2020; Springer Nature B.V
• Subjects: Angiogenesis; Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Blood vessels; Cell adhesion & migration; Cell culture; Cell migration; Chemokine CXCL12 - administration & dosage; Chick Embryo; Chitosan; Chitosan - administration & dosage; Chorioallantoic membrane; Chorioallantoic Membrane - blood supply; Chorioallantoic Membrane - drug effects; Classical Mechanics; Coculture Techniques; Computer simulation; Embryos; Endothelial cells; Endothelial Cells - drug effects; Extracellular matrix; Gelatin; Gelatin - administration & dosage; Glycerophosphates - administration & dosage; Growth factors; Heart function; Hydrogels; Hydrogels - administration & dosage; Mesenchymal Stem Cells - drug effects; Mesenchyme; Muscles; Myocardial infarction; Myocardial Infarction - drug therapy; Myocytes, Smooth Muscle - drug effects; Nanocomposites; Nanocomposites - administration & dosage; Nanoparticles; Nanoparticles - administration & dosage; Neovascularization, Physiologic - drug effects; Oligopeptides - administration & dosage; Original Article; Peptides; Rats, Sprague-Dawley; Regeneration; Room temperature; SDF-1 protein; Smooth muscle; Stem cell transplantation; Stem cells; Tissue Engineering; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - administration & dosage; Vascularization; Nanoparticles; Injectable nanocomposite hydrogel; Tissue repair and regeneration; Vascularization

In this contribution, an injectable hydrogel was developed with chitosan, gelatin, β-glycerphosphate and Arg-Gly-Asp (RGD) peptide: this hydrogel is liquid in room temperature and rapidly gels at 37 °C; RGD peptide promises better growth microenvironment for various cells, especially endothelial cel...