Antiviral Effects of Stichopus japonicus Acid Mucopolysaccharide on Hepatitis B Virus Transgenic Mice

• Published in: Journal of Ocean University of China Vol. 15; no. 4; pp. 719 - 725
• Main Authors: Xin, Yongning, Li, Wei, Lu, Linlin, Zhou, Li, Victor, David W., Xuan, Shiying
• Format: Journal Article
• Language: English
• Published: Heidelberg Science Press 01.08.2016; Springer Nature B.V; Qingdao Municipal Hospital, Qingdao 266071, P.R.China%Department of Gasteroenterology, Qingdao No.6 People's Hospital, Qingdao 266033, P.R.China%Taiyuan Infectious Diseases Hospital, Taiyuan 030000, P.R.China%Hepatology & Transplant Medicine, Department of Medicine, Houston Methodist Hospital, Houston, USA
• Subjects: Earth and Environmental Science; Earth Sciences; Hepatitis; Hepatitis B virus; Liver cancer; Marine; Meteorology; Oceanography; Pathogens; Rodents; Stichopus japonicus; Viruses; transgenic mice; acid mucopolysaccharide; hepatitis B virus; antiviral; Stichopus japonicus acid mucopolysaccharide
• ISSN: 1672-5182; 1993-5021; 1672-5174
• DOI: 10.1007/s11802-016-3124-4

Hepatitis B virus（HBV） is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka（SJAMP） could inhibit HBs Ag and HBe Ag expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP（30 mg kg~（-1））, middle dose SJAMP（40 mg kg~（-1））, high dose SJAMP（50 mg kg~（-1）） and IFN（45 IU kg~（-1）） for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBs Ag and HBc Ag levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.