An unusual subacute progressive motor neuronopathy with myasthenia-like features

The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of con...

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Bibliographic Details
Published inCanadian journal of neurological sciences Vol. 15; no. 3; p. 304
Main Authors Noseworthy, J H, Rae-Grant, A D, Brown, W F
Format Journal Article
LanguageEnglish
Published England 01.08.1988
Subjects
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - pathology
Amyotrophic Lateral Sclerosis - physiopathology
Diagnosis, Differential
Electric Stimulation
Female
Humans
Middle Aged
Myasthenia Gravis - diagnosis
Myasthenia Gravis - pathology
Myasthenia Gravis - physiopathology
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Summary:The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of conjugate gaze paresis and the absence of many of the typical clinical and electromyographic (EMG) findings seen in this condition. The pathological findings were consistent with either a motor neuronopathy or an unusual variant of ALS. We review the clinical and pathological features of this unusual case in this report.
ISSN:0317-1671
DOI:10.1017/S0317167100027797