Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment

Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunc...

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Published inInternational journal of molecular sciences Vol. 23; no. 6; p. 3188
Main Authors Gherghina, Mihai-Emil, Peride, Ileana, Tiglis, Mirela, Neagu, Tiberiu Paul, Niculae, Andrei, Checherita, Ionel Alexandru
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.03.2022
MDPI
Subjects
Adenosine triphosphate
Alzheimer's disease
Dehydrogenases
Enzymes
Humans
Hypertension
Hyperuricemia - metabolism
Hypotheses
Kidneys
Metabolism
Oxidative Stress
Pathogenesis
Quality of Life
Renal Insufficiency, Chronic - complications
Review
Rheumatism
Uric acid
Uric Acid - metabolism
chronic kidney disease
cardiovascular risk
uric acid
outcome
oxidative stress
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms23063188

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Abstract Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin–angiotensin–aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Conclusions: Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients’ long-term prognosis and their quality of life.
AbstractList The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus.BACKGROUNDThe connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus.Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.CONCLUSIONSImportant aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.
Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin–angiotensin–aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Conclusions: Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients’ long-term prognosis and their quality of life.
The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.
Author Neagu, Tiberiu Paul
Peride, Ileana
Checherita, Ionel Alexandru
Niculae, Andrei
Gherghina, Mihai-Emil
Tiglis, Mirela
AuthorAffiliation 3 Department of Plastic Surgery and Reconstructive Microsurgery, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; dr.neagupaul@gmail.com
2 Department of Anesthesiology and Intensive Care, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; mirelatiglis@gmail.com
1 Department of Nephrology, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; gherghina_mihai92@yahoo.com (M.-E.G.); al.checherita@gmail.com (I.A.C.)
AuthorAffiliation_xml – name: 3 Department of Plastic Surgery and Reconstructive Microsurgery, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; dr.neagupaul@gmail.com
– name: 2 Department of Anesthesiology and Intensive Care, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; mirelatiglis@gmail.com
– name: 1 Department of Nephrology, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania; gherghina_mihai92@yahoo.com (M.-E.G.); al.checherita@gmail.com (I.A.C.)
Author_xml – sequence: 1
  givenname: Mihai-Emil
  surname: Gherghina
  fullname: Gherghina, Mihai-Emil
– sequence: 2
  givenname: Ileana
  orcidid: 0000-0002-4912-6590
  surname: Peride
  fullname: Peride, Ileana
– sequence: 3
  givenname: Mirela
  orcidid: 0000-0003-3542-3217
  surname: Tiglis
  fullname: Tiglis, Mirela
– sequence: 4
  givenname: Tiberiu Paul
  orcidid: 0000-0002-4319-1965
  surname: Neagu
  fullname: Neagu, Tiberiu Paul
– sequence: 5
  givenname: Andrei
  orcidid: 0000-0003-2866-8806
  surname: Niculae
  fullname: Niculae, Andrei
– sequence: 6
  givenname: Ionel Alexandru
  orcidid: 0000-0002-9741-5530
  surname: Checherita
  fullname: Checherita, Ionel Alexandru
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35328614$$D View this record in MEDLINE/PubMed
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Keywords chronic kidney disease
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uric acid
outcome
oxidative stress
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Snippet Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal...
The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system....
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SubjectTerms Adenosine triphosphate
Alzheimer's disease
Dehydrogenases
Enzymes
Humans
Hypertension
Hyperuricemia - metabolism
Hypotheses
Kidneys
Metabolism
Oxidative Stress
Pathogenesis
Quality of Life
Renal Insufficiency, Chronic - complications
Review
Rheumatism
Uric acid
Uric Acid - metabolism
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Title Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment
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Volume 23
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