Isolated meningeal chloroma (granulocytic sarcoma): a case report and review of the literature

• Published in: Annals of hematology Vol. 79; no. 8; pp. 459 - 462
• Main Authors: BINDER, C, TIEMANN, M, HAASE, D, HUMPE, A, KNEBA, M
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.08.2000; Springer Nature B.V
• Subjects: Adult; Biological and medical sciences; Combined Modality Therapy; Drug Therapy; Hematologic and hematopoietic diseases; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid - diagnosis; Leukemia, Myeloid - radiotherapy; Leukemia, Myeloid - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Meningeal Neoplasms - diagnosis; Meningeal Neoplasms - radiotherapy; Meningeal Neoplasms - therapy; Nervous system involvement in other diseases. Miscellaneous; Neurology; Human; Antineoplastic agent; Meninge; Acute; Male; Malignant hemopathy; Chloroma; Case study; Myeloproliferative syndrome; Pathology; Chemotherapy; Chronic; Central nervous system disease; Chronic myelocytic leukemia; Adult; Complication; Diagnosis; Bibliographic review; Acute myelocytic leukemia
• ISSN: 0939-5555; 1432-0584
• DOI: 10.1007/s002770000165

Isolated chloromas (granulocytic sarcomas) are rare tumors, most of them progressing to acute myeloblastic leukemia within months. There are still no conclusive treatment strategies for this entity; however, early antileukemic chemotherapy seems to lower the probability of developing systemic disease and prolong survival. We report on a patient with isolated meningeal chloroma, primarily misdiagnosed as a high-grade Non-Hodgkin's lymphoma. Two cycles of antileukemic induction chemotherapy were administered, followed by local irradiation and intensified consolidation therapy with autologous stem cell transplantation. After 20 months, he is still in complete remission.