Mononeuropathy multiplex in Hemophilia: An Electrophysiologic Assessment

• Published in: European neurology Vol. 40; no. 1; pp. 15 - 18
• Main Authors: Chang, Chein-Wei, Shen, Ming-Chin
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.07.1998; S. Karger AG
• Subjects: Adolescent; Adult; Arm - innervation; Biological and medical sciences; Child; Electrophysiology; Femoral Nerve - physiopathology; Hematologic and hematopoietic diseases; Hemophilia A - complications; Hemophilia A - physiopathology; Hemophilia B - complications; Hemophilia B - physiopathology; Humans; Leg - innervation; Male; Median Nerve - physiopathology; Medical sciences; Middle Aged; Neural Conduction; Original Paper; Peripheral Nerves - physiopathology; Peripheral Nervous System Diseases - etiology; Peripheral Nervous System Diseases - physiopathology; Peroneal Nerve - physiopathology; Platelet diseases and coagulopathies; Sural Nerve - physiopathology; Tibial Nerve - physiopathology; Tropical medicine; Ulnar Nerve - physiopathology; Nerve conduction study; Mononeuropathy multiplex; Hemophilia; Human; Nervous system diseases; Hemopathy; Epidemiology; Genetic disease; Nerve conduction; Electrodiagnosis; Characteristics; Complication; Frequency; Peripheral nerve disease; Localization; Coagulopathy
• ISSN: 0014-3022; 1421-9913
• DOI: 10.1159/000007949

Single nerve lesion or mononeuropathy caused by extrinsic compression of hematoma or hemarthrosis is consistently reported for hemophilic patients. To study the manifestation of peripheral nerve lesions, an extensive nerve conduction study of peripheral nerves and specific nerves in correlation with clinical involvement was carried out on 126 hemophilic patients. We found 24 patients with 34 peripheral nerve lesions. The frequency of nerve lesion positively correlated with the severity of hemophilia (p < 0.01) and increasing age (p < 0.05). Nerve lesions occurred more commonly in lower extremities than in upper extremities. The femoral nerve was most commonly involved. Seven patients were identified to have mononeuropathy multiplex with 2 or more nerve lesions involving more than one extremity. All of these patients had chronic condition. Our findings suggest that mononeuropathy multiplex may occur in hemophilic patients.