Controlled Synthesis of 2-Acetyl-6-carbethoxypyridine and 2,6-Diacetylpyridine from 2,6-Dimethylpyridine

The controlled syntheses of mono- and bis-acetylpyridine from the same starting material (2,6-dimethylpyridine) are reported, including the asymmetrical compound 2-acetyl-6-carbethoxypyridine, which has not before been reported. The influences of the amount of catalyst EtONa and the reaction conditi...

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Bibliographic Details
Published inSynthetic communications Vol. 35; no. 17; pp. 2317 - 2324
Main Authors Su, Biyun, Zhao, Jianshe, Cui, Yong, Liang, Yongqing, Sun, Wenhua
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.09.2005
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
Controlled synthesis
EtONa, mono- and bis-acetylpyridine
Physical Sciences
reaction conditions
Science & Technology
EtONa
LIGANDS
COMPLEXES
reaction conditions
IRON
OLIGOMERIZATION
controlled synthesis
ETHYLENE POLYMERIZATION CATALYSTS
mono- and bis-acetylpyridine
COBALT
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Summary:The controlled syntheses of mono- and bis-acetylpyridine from the same starting material (2,6-dimethylpyridine) are reported, including the asymmetrical compound 2-acetyl-6-carbethoxypyridine, which has not before been reported. The influences of the amount of catalyst EtONa and the reaction conditions to the final products are also explored. A modification of the reported preparation for the 2,6-dipicolinic acid, 2,6-dicarbethoxypyridine and 2,6-diacetylpyridine with higher purity and improved yields is provided here, and the physical and spectral properties of these products are identical to those reported in the literature.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910500186995