Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis

• Published in: The Journal of pediatrics Vol. 98; no. 1; pp. 152 - 157
• Main Authors: Kaplan, Sheldon L., Mason, Edward O., Garcia, Haydee, Kvernland, Sally J., Loiselle, Elaine M., Anderson, Donald C., Mintz, A. Aaron, Feigin, Ralph D.
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 1981
• Subjects: Blood-Brain Barrier; Cephalosporins - metabolism; Cephamycins - metabolism; Cephamycins - therapeutic use; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Kinetics; Meningitis, Haemophilus - drug therapy; Meningitis, Meningococcal - drug therapy; Meningitis, Pneumococcal - drug therapy; Moxalactam
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/S0022-3476(81)80562-8

The serum pharmacokinetics and CSF penetration of moxalactam were determined in 39 children with bacterial meningitis. The mean serum concentrations 30 minutes after a 37.5 or 50 mg/kg dose were 66.7 and 113 μg/ml, respectively. The t 1/2β was between 1.8 and 2.0 hours. The mean ±1 SD CSF/serum percentage was 18.5±16.0% (range 2.0 to 61%) for all children on any day of therapy or hour, after the last of three 50 mg/kg doses. Cerebrospinal fluid bactericidal titers were ≥1:32 in 13 of 14 CSF specimens. Moxalactam adequately penetrates into the CSF of children with bacterial meningitis after repetitive 50 mg/kg doses.