Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma

Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 83; no. 9; pp. 1517 - 1530
Main Authors Liu, Tingting, Wang, Juan, Yang, Hongbo, Jin, Qiushi, Wang, Xiaotao, Fu, Yihao, Luan, Yu, Wang, Qixuan, Youngblood, Mark W, Lu, Xinyan, Casadei, Lucia, Pollock, Raphael, Yue, Feng
Format Journal Article
LanguageEnglish
Published United States American Association for Cancer Research 02.05.2023
Subjects
Cancer Landscapes
Enhancer Elements, Genetic
Humans
Liposarcoma
Oncogenes
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Summary:Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.
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T. Liu and J. Wang contributed equally to this article.
Cancer Res 2023;83:1517–30
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-22-1858