Intrafamilial Correspondences on Platelet [ H-]Paroxetine-Binding Indices in Bulimic Probands and their Unaffected First-Degree Relatives

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 31; no. 8; pp. 1785 - 1792
• Main Authors: STEIGER, Howard, GAUVIN, Lise, JOOBER, Ridha, ISRAEL, Mimi, NG YING KIN, N. M. K, BRUCE, Kenneth R, RICHARDSON, Jodie, YOUNG, Simon N, HAKIM, Julie
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.08.2006; Nature Publishing Group
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Blood Platelets - metabolism; Bulimia; Bulimia Nervosa - genetics; Bulimia Nervosa - metabolism; Bulimia Nervosa - psychology; Eating behavior disorders; Female; Humans; Medical sciences; Middle Aged; Neuropharmacology; Paroxetine - metabolism; Pedigree; Pharmacology. Drug treatments; Protein Binding - physiology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Serotonin - metabolism; Tritium - metabolism; bulimia nervosa; Paroxetine; Serotonin; Family study; Psychotropic; Reuptake inhibitor; Eating disorder; Selective serotonin reuptake inhibitor; Endophenotype; Bulimia; paroxetine binding; Platelet; Piperidine derivatives; familial traits; Neurotransmitter; Antidepressant agent
• ISSN: 0893-133X; 1740-634X
• DOI: 10.1038/sj.npp.1301011

Reduced brain serotonin (5-hydroxytryptamine: 5-HT) transporter activity has been associated with susceptibility to various forms of psychopathology, including bulimia nervosa (BN) and related syndromes characterized by appetitive or behavioural dysregulation. We applied density (Bmax) of platelet [3H-]paroxetine binding as a proxy for central 5-HT reuptake activity in two groups of women (33 with BN-spectrum disorders and 19 with no apparent eating or psychiatric disorders), most of these individuals' mothers (31 and 18, respectively), and a small sampling of their sisters (seven and eight, respectively). Hierarchical linear modeling techniques were used to account for nesting of individuals within families and diagnostic groupings. Bulimic probands, their mothers, and their sisters all displayed significantly lower density (Bmax) of platelet-paroxetine binding than did 'control' probands, mothers, or sisters-even when relatives showing apparent eating or psychiatric disturbances were excluded. In addition, in bulimic probands and mothers, significant within-family correlations were obtained on Bmax. These findings imply a heritable trait (or endophenotype), linked to 5-HT activity, and carried by BN sufferers and their first-degree relatives (even when asymptomatic). We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation.