Complexes of aminoglycoside antibiotics with copolymers of acrylamide with acrylic and methacrylic acids

• Published in: Pharmaceutical chemistry journal Vol. 44; no. 6; pp. 314 - 318
• Main Authors: Solovskii, M. V, Eropkin, M. Yu, Eropkina, E. M, Smirnova, M. Yu, Gavrilova, I. I
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer
• Subjects: Acids; Acrylamide; acrylamide copolymers; acrylic and methacrylic acids; Amides; Aminoglycoside antibiotics; Aminoglycosides; Antibacterial activity; Antibacterial agents; Antibiotics; antimicrobial activity; Copolymers; in vitro toxicity; Medicine; Methacrylic acid; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Polyelectrolytes; Polymer complexes; Salts; Toxicity; acrylamide copolymers; acrylic and methacrylic acids; antimicrobial activity; Polymer complexes; aminoglycoside antibiotics; in vitro toxicity
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-010-0458-x

Polymer complexes of aminoglycoside antibiotics as bases with low molecular weight water-soluble copolymers of acrylamide (ACR) with acrylic (AA) and methacrylic (MA) acids containing 15 - 20 mol% carboxyl groups were synthesized. Complexes of antibiotics with ACR-MA copolymers were found to be more stable in aqueous and aqueous salt solutions and to have less toxicity in vitro than complexes based on ACR-AA copolymers. All polymer complexes retained high levels of antibacterial activity.