Complexes of aminoglycoside antibiotics with copolymers of acrylamide with acrylic and methacrylic acids
Polymer complexes of aminoglycoside antibiotics as bases with low molecular weight water-soluble copolymers of acrylamide (ACR) with acrylic (AA) and methacrylic (MA) acids containing 15 - 20 mol% carboxyl groups were synthesized. Complexes of antibiotics with ACR-MA copolymers were found to be more...
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Published in | Pharmaceutical chemistry journal Vol. 44; no. 6; pp. 314 - 318 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Boston : Springer US
01.10.2010
Springer US Springer |
Subjects | |
Online Access | Get full text |
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Summary: | Polymer complexes of aminoglycoside antibiotics as bases with low molecular weight water-soluble copolymers of acrylamide (ACR) with acrylic (AA) and methacrylic (MA) acids containing 15 - 20 mol% carboxyl groups were synthesized. Complexes of antibiotics with ACR-MA copolymers were found to be more stable in aqueous and aqueous salt solutions and to have less toxicity in vitro than complexes based on ACR-AA copolymers. All polymer complexes retained high levels of antibacterial activity. |
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Bibliography: | http://dx.doi.org/10.1007/s11094-010-0458-x ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0091-150X 1573-9031 |
DOI: | 10.1007/s11094-010-0458-x |