Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments

Understanding how proteins facilitate signaling and substrate transport across biological membranes is an important frontier of structural biology. Membrane proteins are the doors and windows of cells: many membrane proteins are gates of entry into or exit from cells or cellular compartments, and ot...

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Bibliographic Details
Published inThe Journal of general physiology Vol. 133; no. 3; pp. 231 - 237
Main Author Gaudet, Rachelle
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 01.03.2009
The Rockefeller University Press
Subjects
Animals
Biology
Cells
Humans
Ions
Membranes
Microscopy
Models, Molecular
Protein Conformation
Proteins
Rats
Transient Receptor Potential Channels - chemistry
Transient Receptor Potential Channels - genetics
Transient Receptor Potential Channels - metabolism
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Summary:Understanding how proteins facilitate signaling and substrate transport across biological membranes is an important frontier of structural biology. Membrane proteins are the doors and windows of cells: many membrane proteins are gates of entry into or exit from cells or cellular compartments, and others allow cells to sense their environment. One important multifunctional family of membrane proteins is the transient receptor potential (TRP) family of ion channels. TRP channels have recently been the subject of multiple structural analyses, both low resolution electron microscopy studies (reviewed by Moiseenkova-Bell and Wensel in this issue [p. 239]) and the divide and conquer approach of determining high resolution crystal structures of channel fragments, reviewed here. [PUBLICATION ABSTRACT]
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ISSN:0022-1295
1540-7748
1540-7748
DOI:10.1085/jgp.200810137