Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

• Published in: International journal of molecular sciences Vol. 21; no. 17; p. 6356
• Main Authors: He, Jin, Zhang, Peiwen, Shen, Linyuan, Niu, Lili, Tan, Ya, Chen, Lei, Zhao, Ye, Bai, Lin, Hao, Xiaoxia, Li, Xuewei, Zhang, Shunhua, Zhu, Li
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.09.2020; MDPI
• Subjects: Adipocytes; Animals; Apoptosis; Asthma; Blood pressure; Energy Metabolism; Enzymes; Fatty acids; Fatty Acids, Volatile - metabolism; Fermentation; Glucagon; Glucose; Glucose - metabolism; Humans; Inflammation; Inflammation - metabolism; Inflammation - physiopathology; Insulin; Kinases; Lipid Metabolism; Lipids; Liver; Metabolism; Microorganisms; Peptides; Physiology; Proteins; Researchers; Review; Signal Transduction; Smooth muscle; glycose and lipid metabolism; signalling pathways; short-chain fatty acids; inflammation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21176356

Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.