Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood

• Published in: Behavioural brain research Vol. 187; no. 1; pp. 190 - 194
• Main Authors: Bhagya, V., Srikumar, B.N., Raju, T.R., Shankaranarayana Rao, B.S.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 11.02.2008; Elsevier Science
• Subjects: Adult and adolescent clinical studies; Animals; Animals, Newborn - physiology; Antidepressive Agents, Tricyclic - pharmacology; Behavioral psychophysiology; Biological and medical sciences; Clomipramine - pharmacology; Depression; Depressive Disorder - chemically induced; Depressive Disorder - psychology; Female; Forced swim test; Fundamental and applied biological sciences. Psychology; Hippocampus; Learning Disorders - chemically induced; Learning Disorders - psychology; Medical sciences; Memory - drug effects; Memory, Short-Term - drug effects; Mood disorders; Motor Activity - drug effects; Motor Activity - physiology; Neuropharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychomotor Performance - drug effects; Psychopathology. Psychiatry; Psychopharmacology; Radial arm maze; Rats; Rats, Wistar; Serotonin; Spatial memory; Sucrose consumption test; Radial arm maze; Sucrose consumption test; Forced swim test; Serotonin; Hippocampus; Spatial memory; Neonatal; Rat; Sucrose; Psychotropic; Central nervous system; Cognition; Reuptake inhibitor; Clomipramine; Encephalon; Learning; Endogenous; Acquisition process; Adult; Antidepressant agent; Human; Mood disorder; Rodentia; Depression; Catecholamine; Tricyclic compound; Vertebrata; Mammalia; Animal; Neurotransmitter; Norepinephrine; Arm; Dibenzazepine derivatives
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2007.08.020

Clinical studies show cognitive impairment in depression. However, the neural substrates underlying these remain elusive. Hence, we have examined the effect of neonatal clomipramine treatment on cognition in adulthood. The neonatal clomipramine treated rats displayed a profound impairment in partially baited 8-arm radial maze task. This work provides a novel perspective into neural basis of depression associated cognitive changes and help in development of therapeutic strategies to treat depression related memory dysfunctions.