A seminal perspective on the role of chondroitin sulfate in biomineralization

Chondroitin sulfate (CS) is an important extracellular matrix component of mineralized tissues. It participates in biomineralization, osteoblast differentiation and promotes bone tissue repair in vitro. However, the mechanism in which CS functions is unclear. Accordingly, an in-depth investigation o...

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Bibliographic Details
Published inCarbohydrate polymers Vol. 310; p. 120738
Main Authors Hao, Jia-xin, Wan, Qian-qian, Mu, Zhao, Gu, Jun-ting, Yu, Wei-wei, Qin, Wen, Li, Yu-tao, Wang, Chen-yu, Ma, Yu-xuan, Jiao, Kai, Tay, Franklin, Niu, Lina
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.06.2023
Subjects
Amorphous calcium phosphate
Biomineralization
Bone and Bones - metabolism
Chondroitin sulfate
Chondroitin Sulfates - pharmacology
Collagen - metabolism
Extracellular Matrix - metabolism
Heterotopic ossification
Intrafibrillar mineralization
Proteoglycans
EDC
HO
DLS
SAED
Intrafibrillar mineralization
CaP
HYAL1
Rg
FTIR
MD
EDX
NHS
Heterotopic ossification
CLSM
HPLC
Proteoglycans
Amorphous calcium phosphate
CS-ACP
GAG
ACP
ECM
CS
SEM
Chondroitin sulfate
HAADF-STEM
ChABC
TEM
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Summary:Chondroitin sulfate (CS) is an important extracellular matrix component of mineralized tissues. It participates in biomineralization, osteoblast differentiation and promotes bone tissue repair in vitro. However, the mechanism in which CS functions is unclear. Accordingly, an in-depth investigation of how CS participates in mineralization was conducted in the present study. Chondroitin sulfate was found to directly induce intrafibrillar mineralization of the collagen matrix. The mineralization outcome was dependent on whether CS remained free in the extracellular matrix or bound to core proteins; mineralization only occurred when CS existed in a free state. The efficacy of mineralization appeared to increase with ascending CS concentration. This discovery spurred the authors to identify the cause of heterotopic ossification in the Achilles tendon. Chondroitin sulfate appeared to be a therapeutic target for the management of diseases associated with heterotopic calcification. A broader perspective was presented on the applications of CS in tissue engineering. [Display omitted]
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ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2023.120738