Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival

Abstract The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased...

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Published inClinical infectious diseases Vol. 74; no. 6; pp. 1081 - 1084
Main Authors Das Adhikari, Upasana, Eng, George, Farcasanu, Mara, Avena, Laura E, Choudhary, Manish C, Triant, Virginia A, Flagg, Meaghan, Schiff, Abigail E, Gomez, Isabella, Froehle, Leah M, Diefenbach, Thomas J, Ronsard, Larance, Lingwood, Daniel, Lee, Grace C, Rabi, Seyed Alireza, Erstad, Derek, Velmahos, George, Li, Jonathan Z, Hodin, Richard, Stone, James R, Honko, Anna N, Griffiths, Anthony, Yilmaz, Ömer H, Kwon, Douglas S
Format Journal Article
LanguageEnglish
Published US Oxford University Press 23.03.2022
Subjects
Brief Reports
COVID-19
Feces
Gastrointestinal Tract
Humans
RNA, Viral
SARS-CoV-2 - genetics
GI epithelium
fecal
RNA
organoids
mortality
phylogenetics
SARS CoV-2
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Summary:Abstract The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased coronavirus disease 2019 (COVID-19) survival. Measurement of SARS-CoV-2 RNA in stool may have utility for clinical risk assessment.
Bibliography:ObjectType-Article-1
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U. D. A., G. E., and M. F. contributed equally to this work.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciab623