Hyperviscosity in the neonate

Clinical and blood viscosity studies were performed in a group of 18 polycythemic newborn infants. The infants had signs and symptoms such as plethora, cyanosis, respiratory distress, central nervous system manifestations, hyperbilirubinemia, thrombocytopenia, fragemented red cells, and hypoglycemia...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 82; no. 6; pp. 1004 - 1012
Main Authors Gross, Gary P., Hathaway, William E., McGaughey, H. Raymond
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.06.1973
Subjects
Blood
Blood Transfusion
Blood Viscosity
Cyanosis - blood
Electroencephalography
Erythrocytes
Erythrocytes, Abnormal
Female
Hematocrit
Humans
Hydrogen-Ion Concentration
Hyperbilirubinemia - blood
Infant, Newborn
Infant, Newborn, Diseases - blood
Male
Polycythemia - blood
Syndrome
Umbilical Cord
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Summary:Clinical and blood viscosity studies were performed in a group of 18 polycythemic newborn infants. The infants had signs and symptoms such as plethora, cyanosis, respiratory distress, central nervous system manifestations, hyperbilirubinemia, thrombocytopenia, fragemented red cells, and hypoglycemia. The whole blood of these infants showed increased viscosity when compared to normal limits for healthy newborn infants. The pathogensis of the clinical manifestations associated with hyperviscosity is discussed. Studies indicate the possible importance of erythrocyte deformability in hyperviscosity of the neonate. The newborn infant is uniquely susceptible to developing hyperviscosity. Clinical manifestations associated with hyperviscosity may results in permanent sequenllae in these infants. Partial exchange transfusion results in an improvement in the whole blood viscosity which is associated with an improved clinical course.
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ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(73)80433-0